منابع مشابه
Glucose metabolism in cancer cells.
PURPOSE OF REVIEW Cancer cells alter their metabolism in order to support their rapid proliferation and expansion across the body. In particular, tumor cells, rather than fueling glucose in the oxidative phosphorylation pathway, generally use glucose for aerobic glycolysis. In this review, we discuss some of the mechanisms thought to be responsible for the acquisition of a glycolytic phenotype ...
متن کاملGlucose Metabolism and Cancer
Lei Zheng1,2, Jiangtao Li2 and Yan Luo3 1The Sidney Kimmel Comprehensive Cancer Center, The Skip Viragh Center for Pancreatic Cancer, The Sol Goldman Pancreatic Cancer Center Department of Oncology, and Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland 2Department of Surgery, The Second Affiliated Hospital Zhejiang University College of Medicine, Hangzh...
متن کاملMetformin, cancer and glucose metabolism.
Metformin is the first-line treatment for type 2 diabetes. Results from several clinical studies have indicated that type 2 diabetic patients treated with metformin might have a lower cancer risk. One of the primary metabolic changes observed in malignant cell transformation is an increased catabolic glucose metabolism. In this context, once it has entered the cell through organic cation transp...
متن کاملTargeting glucose metabolism in patients with cancer.
Nearly a century ago, Otto Warburg made the astute observation that the metabolic properties of cancer cells differ markedly from those of normal cells. Several decades passed before the concept of exploiting cancer cell metabolism came into clinical practice with the advent of chemotherapy, the underlying principle of which is to target rapidly dividing cells by interfering with critical proce...
متن کاملAbnormal glucose metabolism and pancreatic cancer mortality.
CONTEXT Previous studies reported an increased risk of pancreatic cancer among persons with diabetes. Few data exist, however, on the association of postload plasma glucose concentration with pancreatic cancer, which could provide insight into the role of abnormal glucose metabolism in the etiology of pancreatic cancer. OBJECTIVE To determine the independent association between postload plasm...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2003
ISSN: 0021-9258
DOI: 10.1074/jbc.m307031200